Combination of polymorphisms in OB-R and the OB gene associated with insulin resistance in Nauruan males
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چکیده
منابع مشابه
Peripheral nervous system insulin resistance in ob/ob mice
BACKGROUND A reduction in peripheral nervous system (PNS) insulin signaling is a proposed mechanism that may contribute to sensory neuron dysfunction and diabetic neuropathy. Neuronal insulin resistance is associated with several neurological disorders and recent evidence has indicated that dorsal root ganglion (DRG) neurons in primary culture display altered insulin signaling, yet in vivo resu...
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15 صفحه اولLeptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice.
Leptin controls feeding behavior and insulin secretion from pancreatic beta-cells. Insulin stimulates the production of leptin, thereby establishing an adipoinsular axis. Earlier we identified leptin receptors on pancreatic beta-cells and showed leptin-mediated inhibition of insulin secretion by activation of ATP-sensitive potassium channels. Here we examine transcriptional effects of leptin on...
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Leptin, a hormone of the cytokine family, is mainly synthesized by white adipocytes. As fibroblasts and adipocytes share a common stem cell origin, we hypothesized that connective tissue may be another candidate for leptin synthesis. We demonstrated leptin receptors, inclusive of all isoforms, on cultured fibroblasts (n = 13) by RT-PCR and immunohistochemistry. In contrast to its receptor, basa...
متن کاملIsolated adipocytes from growth hormone-treated obese (ob/ob) mice exhibit insulin resistance.
The genetically obese (ob/ob) mouse is a useful model for the study of the diabetogenic action of growth hormone (GH), because treatment of these animals with GH results in decreased responsiveness of their adipose tissue to insulin in vitro. Studies of the mechanisms involved in GH-induced insulin resistance using isolated adipocytes of ob/ob mice have not been possible, however, because of th...
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ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 1999
ISSN: 0307-0565,1476-5497
DOI: 10.1038/sj.ijo.0800931